research achievement

Katagiri D, Tsukada A, Izumi S, Shimizu Y, Terada-Hirashima J, Uemura Y, Kusaba Y, Takasaki J, Takoi H, Tamura-Nakano M, Hojo M, Takano H, Noiri E, Abe S, Azuma A, Sugiyama H.
Blood perfusion with polymyxin B immobilized columns in patients with COVID-19 requiring oxygen therapy.
Sci Rep. 2024 May 31;14(1):12550. doi: 10.1038/s41598-024-63330-2. PMID: 38822071; PMCID: PMC11143350.

Junko Terada-Hirashima, Yuki Takamatsu, Yosuke Shimizu, Yukari Uemura, Junko S Takeuchi, Noriko Tomita, Kouki Matsuda, Kenji Maeda, Shohei Yamamoto, Ami Fukunaga, Norio Ohmagari, Ayako Mikami, Kengo Sonoda, Mugen Ujiie, Hiroaki Mitsuya, Wataru Sugiura, Immunogenicity and safety of single booster dose of KD-414 inactivated COVID-19 vaccine in adults: An open-label, single-center, non-randomized, controlled study in Japan, Hum Vaccin Immunother. 2023 Dec 31;19(1):2193074. doi:10.1080/21645515.2023.2193074. Epub 2023 Apr 13.

Ayako Mikami, Junko Terada-Hirashima, Daisuke Tokita, Wataru Sugiura, Clinical trial experience in Japan and future issues in developing drugs to treat COVID-19, Glob Health Med. 2023 Apr 30;5(2):85-91. doi: 10.35772/ghm.2023.01022.

Noriko Tomita, Junko Terada-Hirashima, Yukari Uemura, Yosuke Shimizu, Haruka Iwasaki, Rina Yano, Tetsuya Suzuki, Sho Saito, Nobumasa Okumura, Wataru Sugiura, Norio Ohmagari, Mugen Ujiie, An open-label, non-randomized study investigating the safety and efficacy of smallpox vaccine, LC16, as post-exposure prophylaxis for mpox, Hum Vaccin Immunother. 2023 Aug 1;19(2):2242219. doi: 10.1080/21645515.2023.2242219.

Rina Yano, Junko Terada-Hirashima, Yukari Uemura, Noriko Tomita, Yosuke Shimizu, Haruka Iwasaki, Nobumasa Okumura, Tetsuya Suzuki, Sho Saito, Mugen Ujiie, Wataru Sugiura, Norio Ohmagari, Efficacy and Safety of the Smallpox Vaccine for Postexposure Prophylaxis in Monkeypox: Protocol for an Open-Labeled, Single-Armed Study, JMIR Res Protoc. 2023 Aug 25;12:e46955. doi: 10.2196/46955.

Terada-Hirashima J, Mizushima D, Takano M, Tokita D, Oka S.
Efficacy and Safety of Pre-Exposure Prophylaxis to Control HIV and Sexually Transmitted Infection Among Men Who Have Sex With Men: Protocol for a Single-Arm Interventional Study. JMIR Res Protoc. 12（e50919), 2023.

Suzuki M, Matsunaga A, Miyoshi-Akiyama T, Terada-Hirashima J, Sadamasu K, Nagashima M, Takasaki J, Izumi S, Hojo M, Ishizaka Y, Sugiyama H.
Inhaled ciclesonide does not affect production of antibodies or elimination of virus in patients with COVID-19: Subanalysis of a multicenter, open-label randomized trial. Drug Discov Ther. 17(5):304-311, 2023.

Terada-Hirashima J, Sugiura W, Shimizu Y, Tanaka Y, Uemura Y, Ishikane M, Kazuyama Y, Ikeda M, Wakabayashi K, Ohmagari N, Kimura M, Investigation of the use of PCR testing prior to ship boarding to prevent the spread of SARS-CoV-2 from urban areas to less populated remote islands. Global Health & Medicine, 30;4(3):174-179, 2022. (Jun)

Terayama Y, Tomita N, Terada-Hirashima J, Uemura Y, Shimizu Y, Takeuchi JS, Takamatsu Y, Maeda K, Mikami A, Ujiie M, Sugiura W, Protocol of an Exploratory Single-Arm Study to Evaluate the Safety and Immunogenicity of KD-414 as a Booster Vaccine for SARS-CoV-2 in Healthy Adults (KAPIVARA). Life, 12(7):966, 2022. (Jun)

Tomita N, Saito S, Terada-Hirashima J, Mikami A, Uemura Y, Kutsuna S, Nomoto H, Fujisawa K, Nagashima M, Terada M, Ashida S, Morioka S, Satake M, Hangaishi A, Togano T, Shiratori K, Takamatsu Y, Maeda K, Ohmagari N, Sugiura W, Mitsuya H, A Multi-Center, Open-Label, Randomized Controlled Trial to Evaluate the Efficacy of Convalescent Plasma Therapy for Coronavirus Disease 2019: A Trial Protocol (COVIPLA-RCT). Life, 12(6):856, 2022. (Jun)

Terada-Hirashima J, Izumi S, Katagiri D, Uemura Y, Mikami A, Sugiura W, Abe S, Azuma A, Sugiyama H. Efficacy and Safety of Direct Hemoperfusion using Polymyxin B-Immobilized Polystyrene Column (PMX-DHP) for COVID-19 Patients: Exploratory Study Protocol. JMIR Res Protoc. 2022 Sep 1. doi: 10.2196/37426. Epub ahead of print. PMID: 36126219.

Tomita N, Morino E, Terada-Hirashima J, Uemura Y, Shimizu Y, Saito S, Suzuki T, Okumura N, Iwasaki H, Ebihara H, Shimojima M, Sugiura W, Ohmagari N, Ujiie M, Evaluating the Immunogenicity and Safety of a Smallpox Vaccine to Monkeypox in Healthy Japanese Adults: A Single-Arm Study. Life, 13(3):787, 2023. (Mar)

Matsunaga N, Hayakawa K, Terada M, Ohtsu H, Asai Y, Tsuzuki S, Suzuki S, Toyoda A, Suzuki K, Endo M, Fujii N, Suzuki M, Saito Sho, Uemura Y, Shibata T, Kondo M, Izumi K, Terada-Hirashima J, Mikami A, Sugiura W, Ohmagari N, Clinical epidemiology of hospitalized patients with COVID-19 in Japan: Report of the COVID-19 REGISTRY JAPAN. Clinical Infectious Disease, 6;73(11): e3677-e3689, 2021 (Dec)

Kenji Maeda, Masayuki Amano, Yukari Uemura, Kiyoto　Tsuchiya, Tomoko Matsushima, Kenta Noda, Yosuke Shimizu, Asuka Fujiwara, Yuki Takamatsu, Yasuko Ichikawa, Hidehiro Nishimura, Mari Kinoshita, Shota Matsumoto, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Shin-Ichi Oka, Ayako Mikami, Wataru Sugiura, Toshiyuki Sato, Tomokazu Yoshida, Shinya Shimada, Hiroaki Mitsuya, Correlates of neutralizing/SARS-CoV-2-S1-binding antibody response with adverse effects and immune kinetics in BNT162b2-vaccinated individuals.　Scientific Reports, 24;11(1):22848, 2021. (Nov)

Tsujimoto Y, Terada J, Kimura M, Moriya A, Motohashi A, Izumi S, Kawajiri K, Hakkaku K, Morishita M, Saito S, Takumida H, Watanabe H, Tsukada A, Morita C, Yamaguchi Y, Katsuno T, Kusaba Y, Sakamoto K, Hashimoto M, Suzuki M, Takasaki J, Hojo M, Miyoshi-Akiyama T, Sugiyama H. Diagnostic accuracy of nasopharyngeal swab, nasal swab and saliva swab samples for the detection of SARS-CoV-2 using RT-PCR. Infectious Disease (London, England), 53(8):581-589, 2021 (Aug)

Yoshie Tsujimoto, Junko Terada, Moto Kimura, Ataru Moriya, Ayano Motohashi, Shinyu Izumi, Kazuki Kawajiri, Kazuo Hakkaku, Momoko Morishita, Susumu Saito, Hiroshi Takumida, Hiromu Watanabe, Akinari Tsukada, Chie Morita, Yoh Yamaguchi, Takashi Katsuno, Yusaku Kusaba, Keita Sakamoto, Masao Hashimoto, Manabu Suzuki, Jin Takasaki, Masayuki Hojo, Tohru Miyoshi-Akiyama, Haruhito Sugiyama, Diagnostic accuracy of nasopharyngeal swab, nasal swab and saliva swab samples for the detection of SARS-CoV-2 using RT-PCR. Infectious Diseases (Lond), 53(8):581-589, 2021 (Aug)

Katsuno T, Suzuki M, Hojo M, Terada J, Nakamura K, Suzuki T, Miyazato Y, Sugiyama H, Clinical experience with high-flow nasal cannulas for coronavirus disease 2019 patients in Japan. Respiratory Investigation, 59(4):569-572, 2021 (Jul)

Akinari Tsukada, Manabu Suzuki, Yuya Kishino, Kento Misumi, Toru Igari, Noriko Nakajima, Yuko Sato, Tadaki Suzuki, Takashi Katsuno, Yusaku Kusaba, Yoshie Tsujimoto, Keita Sakamoto, Masao Hashimoto, Junko Terada, Jin Takasaki, Shinyu Izumi, Masayuki Hojo, Haruhito Sugiyama, A Kidney Transplant Patient Who Died of COVID-19-associated Severe Acute Respiratory Distress Syndrome. Internal Medicine, 15;60(14):2297-2300,2021 (Jul)

Saito S, Hayakawa K, Mikami A, Izumi S, Funazaki H, Ashida S, Sugiura W, Sugiyama H, Kokudo N, Ohmagari N, Investigator initiated clinical trial of remdesivir for the treatment of COVID-19 in Japan. Global Health & Medicine, 3(2):62-66, 2021. (Apr)

Hojo M, Terada-Hirashima J, Sugiyama H, COVID-19 and bronchial asthma: current perspectives. Global Health & Medicine, 3(2):67-72, 2021. (Apr)

Kenta Noda, Kouki Matsuda, Shigehiro Yagishita, Kenji Maeda, Yutaro Akiyama, Junko Terada-Hirashima, Hiromichi Matsushita, Satoshi Iwata, Kazuto Yamashita, Yusuke Atarashi, Shunsuke Watanabe, Nobuyuki Ide, Tomokazu Yoshida, Norio Ohmagari, Hiroaki Mitsuya, Akinobu Hamada, A novel highly quantitative and reproducible assay for the detection of anti-SARS-CoV-2 IgG and IgM antibodies. Scientific Reports, 4;11(1):5198, 2021 (Mar)

Yagi K, Ito A, Fujiwara K, Morino E, Hase I, Nakano Y, Asakura T, Furuuchi K, Morita A, Asami T, Namkoong H, Saito F, Morimoto K, Ishii M, Sato Y, Tateno H, Nishio K, Oyamada Y, Fukunaga K, Sugiyama H, Ishida T, Kurashima A, Hasegawa N, Clinical Features and Prognosis of Nontuberculous Mycobacterial Pleuritis: A Multicenter Retrospective Study. Ann Am Thorac Soc. 2021 Sep;18(9):1490-1497.

Terada-Hirashima J, Suzuki M, Uemura Y, Hojo M, Mikami A, Sugiura W, Ohmagari N, Sugiyama H, Efficacy and Safety of Inhaled Ciclesonide in Treating Patients with Asymptomatic or Mild COVID-19 in the RACCO Trial: Protocol for a Multicenter, Open-label, Randomized Controlled Trial. JMIR Research Protocol, 9(12): e23830, 2020. (Dec)

Katsuno T, Suzuki M, Ishikane M, Kinoshita N, Tsukada A, Morita C, Kusaba Y, Sakamoto K, Yamaguchi Y, Tsujimoto Y, Hashimoto M, Terada J, Takasaki J, Izumi S, Okuhama A, Ide S, Moriyama Y, Matsuda K, Takamatsu Y, Mitsuya H, Hojo M, Sugiyama H, A familial cluster of severe coronavirus disease 2019 that required intubation of all family members. Infectious Diseases, 52(10):755-758, 2020. (Oct)

Yuriko Ueki, Manabu Suzuki, Yuriko Horikawa, Hiromu Watanabe, Yoh Yamaguchi, Chie Morita, Akinari Tsukada, Hiroshi Takumida, Yusaku Kusaba, Takashi Katsuno, Yoshie Tsujimoto, Keita Sakamoto, Masao Hashimoto, Junko Terada, Satoru Ishii, Jin Takasaki, Go Naka, Motoyasu Iikura, Shinyu Izumi, Yuichiro Takeda, Masayuki Hojo, Haruhito Sugiyama, Pembrolizumab-induced pancytopenia in a patient with squamous cell lung cancer. Thoracic Cancer, 11(9):2731-2735, 2020 (Sep)

Katagiri D, Ishikane M, Asai Y, Kinoshita N, Ota M, Moriyama Y, Ide S, Nakamura K, Nakamoto T, Nomoto H, Akiyama Y, Miyazato Y, Suzuki T, Okuhama A, Kanda K, Wakimoto Y, Morioka S, Saito S, Yamamoto K, Ujiie M, Hayakawa K, Kustuna S, Yanagawa Y, Terada J, Takasaki J, Izumi S, Hojo M, Hinoshita F, Sugiyama M, Noiri E, Mizokami M, Ohmagari N, Sugiyama H, Evaluation of Coronavirus Disease 2019 Severity Using Urine Biomarkers. Critical Care Explorations, 2(8): e0170, 2020. (Jul)

Daisuke Katagiri, Masahiro Ishikane, Yusuke Asai, Noriko Kinoshita, Masayuki Ota, Yuki Moriyama, Satoshi Ide, Keiji Nakamura, Takato Nakamoto, Hidetoshi Nomoto, Yutaro Akiyama, Yusuke Miyazato, Tetsuya Suzuki, Ayako Okuhama, Kohei Kanda, Yuji Wakimoto, Shinichiro Morioka, Sho Saito, Kei Yamamoto, Mugen Ujiie, Kayoko Hayakawa, Satoshi Kustuna, Yasuaki Yanagawa, Junko Terada, Jin Takasaki, Shinyu Izumi, Masayuki Hojo, Fumihiko Hinoshita, Masaya Sugiyama, Eisei Noiri, Masashi Mizokami, Norio Ohmagari, Haruhito Sugiyama, Evaluation of Coronavirus Disease 2019 Severity Using Urine Biomarkers. Critical Care Explorations, 31;2(8):e0170, 2020 (Jul)

Ito K, Ohmagari N, Mikami A, Sugiura W, Major ongoing clinical trials for COVID-19 treatment and studies currently being conducted or scheduled in Japan. Global Health & Medicine, 2(2):96-101, 2020. (Apr)

Koh Nakata, Tatsuki Sugi, Keiko Kuroda, Kazutaka Yoshizawa, Toshinori Takada, Ryushi Tazawa, Takahiro Ueda, Ami Aoki, Mitsuhiro Abe, Koichiro Tatsumi, Ryosuke Eda, Shotaro Kondoh, Konosuke Morimoto, Takeshi Tanaka, Etsuro Yamaguchi, Ayumu Takahashi, Miku Oda, Haruyuki Ishii, Shinyu Izumi, Haruhito Sugiyama, Atsushi Nakagawa, Keisuke Tomii, Masaru Suzuki, Satoshi Konno, Shinya Ohkouchi, Taizou Hirano, Tomohiro Handa, Toyohiro Hirai, Yoshikazu Inoue, Toru Arai, Katsuaki sakawa, Takuro Sakagami, Takahiro Tanaka, Ayako Mikami, Nobutaka Kitamura, Validation of a new serum granulocyte-macrophage colony-stimulating factor autoantibody testing kit. ERJ Open Research, 27;6(1):00259-2019. 2020. (Jan)